All too often the design of pharmaceutical OSD production facilities fails to recognise the impacton, and the opportunities for, materials handling. In this article, we consider a range of different options for materials handling, the benefits and challenges in each case, and the relationship between materials handling and facility design.
Whereas the production processes themselves are easy to define and understand – for example, it is a straightforward task to design a room that fits a tablet press, even if the specific type of machine is undefined – there are many ways to feed to and from
In the case of a tablet press, the powders or granules can be tipped by hand or vacuum conveyed into the inlet of the machine, so a lower height ceiling is acceptable.
Alternatively, drums or Intermediate Bulk Containers (IBCs) can be used to feed the tablet
press by gravity. However, a taller room height would be a requirement to accommodate this system. A further option is to feed product from a mezzanine level or through-floor from a materials handling floor above – in this case the height of the compression room can be minimised, but a second production floor level needs to be considered in the facility design.
At the output of the compression process there are more decisions to be made:
Tablets can be received into small tubs, boxes or drums, or collected in larger IBCs within the room, transferred through wall for collection in an adjacent area, or fed through-floor for collection below. It may also be possible to connect the outlet of the tablet press directly to the inlet of a coater or packing machine.
This example only considers one stage of the process – compression – however it lustrates the wide range of materials handling configurations that need to be considered and the impact that these decisions have on the overall facility design.
On the other hand, if you already have an existing facility, then some of these materials handling options will not be available to you. In this case the challenge is to find the optimum materials handling solution that will fit in the space available.
Whether considering a new production facility, or upgrading an existing one, the way that powders, granules, tablets and capsules are moved, stored, fed to and collected from processes has a fundamental impact on how the facility operates: its capacity, flexibility, expandability and cost of production.
Making the right decision at the right stage of the project
Whether you are building a new production facility, or modifying an existing one, the chances are that you will have a good understanding of the process steps that are required at an early stage of the project.
Once the process is defined, the next question should be ‘How are the materials (i.e. the powders, granules, tablets and capsules) moved from one process step to another?’, ‘Do the materials flow easily without operator intervention?’ and ‘What is the best way to do this?’. All too often companies fix the facility layout without fully considering these fundamental questions – the result of which is to limit or compromise on the ideal materials handling solutions.
With materials handling there is not a ‘one size fits all’ solution. Requirements can vary significantly from one project to the next. Factors such as production throughout, number of materials/SKUs, containment requirements, material characteristics,
-Keeps the building costs low. The use of small containers and manual operations enables this approach to be used in single floor facilities with small production rooms.
– Non-contained operation and open transfers increase the risk of contamination and crosscontamination.
– Challenges to inventory control and traceability. As the batch is split into many small sub-lots, this requires manual activities to track each container and results in crowded GMP production areas. As the number of sub-lots increases then the risk for error escalates.
– Labour intensive/reliant, with associated health and safety risks as operators often carry out manual lifting and handling of the containers and materials.
– Container cleaning is more labour intensive due to larger numbers. Sometimes it is possible to upgrade these existing facilities with improved ways of handling powders,
granules, tablets and capsules, focussing on bottlenecks in production and considering lean ways to handle materials. However, all too often the constraints of an existing building prevent the use of optimal materials handling solutions.
– Limited production capacity, as the production batch is handled in many small sub-lots and requires lots of manual operations, with transfers being slow and inefficient.
– Low capital cost for material handling as boxes, drums etc. are cheaper to purchase
This materials handling approach is normally seen in facilities – or areas of the process
– where height and space constraints prevent other options being used. It can also be used where disposable containers are utilised, resulting in charges for safe disposal. However, this traditional approach also has several disadvantages:
– This is not a lean approach, as large numbers of containers mean lots of vessel ovements, more connections/disconnections, additional cleaning and extra storage.
3. IBC Systems
IBC Systems enable the handling of larger batches in a single container, replacing the many drums, tubs and boxes.
The benefits of IBC Systems include:
– Fewer containers are required per batch.
– Reduced movements of tablet containers.
– The number of connections/disconnections are reduced.
– Less space is required for storage of containers (when empty and inter-process)
– Reduced cleaning requirement.
– More efficient and simpler traceability.
How many production floors?
Having decided which materials handling methodology is most suitable, building design is then the next focus.
All over the world, wherever new solid dosage facilities are being built, fundamental choices are being made between building a single-floor or multi-floor plant – and, if multi-floor, then how many floors?
When land is expensive, it makes sense to consider building upwards rather than outwards with a larger footprint. The design of the new facility also needs to balance the future capacity requirements, as well as the requirements on ‘day 1’ whilst considering the
higher investment costs now verses a high modification cost or missed opportunity costs later.
1. Single-floor facility
In a single-floor configuration, IBCs can be used to connect one process to another. By matching the volume of the IBC System to the volume of the batch processes, then full batch transfer can be achieved. This means that only one connection/disconnection is required between the IBC System and each process.
Single-floor facilities can have the lowest cost ofconstruction, but they have constraints with regards to the materials handling solutions. To benefit from direct gravity feed, pillar lifts are often used to position IBCs above each process, which means that you must allow for enough height in the room design to allow the IBCs to be raised up. If the ceiling height is fixed, and too low, you will have to use methodology 2, of boxes and drums, which will require floor space to accommodate the number needed to process a batch.
Frames or mezzanines are alternative ways to achieve gravity feed in single-floor facilities if the building height and layout can accommodate this.
2. Two floor facility
As illustrated by the process flow diagram, a twofloor approach enables the top floor to be dedicated to materials handling and blending, with the tableting and packing processes taking place on the lower floor. In this case, pillar lifts are not required, and the height and size of the process rooms can be reduced significantly. The GMP production areas are less crowded and the smaller production rooms are lower cost to construct, maintain and clean.
The top floor can be an open materials handling floor. However, to achieve this, it is important to ensure closed connections before, during and after IBC Discharge to provide a dust-tight transfer and avoid the risk of contamination and cross-contamination. Alongside this, the correct solution for gently transferring sensitive materials through-floor also needs to be addressed. If poor material flow is a possibility, then methods of smoothly and consistently emptying containers must be considered without operator intervention.
This two-floor arrangement also makes it possible to use larger volume IBCs, enabling production ‘lots’ to be consolidated into larger batch sizes for a leaner approach to manufacturing. As fewer IBCs are required, the number of IBC movements, connections/disconnections, cleaning requirements and storage space are all reduced.
Multiple floor facility
Using more than 2 floors for production introduces a different type of concept: the ability to separate GMP process floors from technical materials handling floors.
The materials handling floors can have a lower area classification as the IBC Discharge Systems and IBC Filling Systems provide separation between the GMP and technical floors. Again, large sized IBCs are ideal for materials handling and can utilise the height of the rooms to maximum effect.
In addition, automation of IBC movements using Automatic Guided Vehicles (AGVs) and automation of cleaning and drying using Clean-In-Place (CIP) equipment, can remove the need for operators on the materials handling floors.
Although this multi-floor arrangement can offer lower cost of manufacture, the investment in the building construction and the high level of automation is only appropriate in certain cases.
Based on our experience working with pharmaceutical companies around the world, we would urge you to consider four key points when evaluating your materials handling requirements:
1. There are many different options for materials handling in pharmaceutical OSD production facilities; no ‘one size fits all’ solution and requirements can vary significantly from one application to the next.
2. The way that materials are moved through the facility has an impact on the effectiveness and cost of pharmaceutical manufacture, the specification of the process machines and the design of the facility itself.
3. Current materials may flow easily, but future products may not.
4. For new facilities, it is important to review materials handling early in the process, and before the facility design is fixed.
5. Whilst an existing facility design may limit the options available for materials handling, often there are opportunities to significantly improve the way that materials handling is carried out.
The materials handling approach is a fundamental decision for any production facility and it is important that the right choices are made at the right time.
If you would like to discuss the options in further detail, along with how Matcon can add value to your facility, please visit www.matconibc.com for further information.